Effect of Deferoxamine on Blood-brain Barrier Disturbances following Subarachnoid Haemorrage in Cats

Disruption of the blood brain barrier plays a significant role in the pathophysiology of subarachnoid haemorrhage. Experimental studies concerning subarachnoid haemorrhage suggested the primary role of free radicals and subsequently lipid peroxidation in the pathogenesis of vasospasm. In this experimental study the role of deferoxamine on blood brain barrier disturbance in vasospasm was evaluated. Deferoxamine was used to inhibit the free radical reactions and lipid peroxidation in cats with subarachnoid haemorrhage. Despite the absence of morphological findings of vasospasm in cats with subarachnoid haemorrhage treated with deferoxamine. horseradish peroxidase partides were observed in the cytoplasm of vessels which indicates disturbance of bloodbrain barrier. This result suggested that deferoxamine has no primary role in blood brain barrier disturbance.